PARK21 genetic Parkinson's disease (PD)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

PARK21 genetic Parkinson's disease (PD). This is probably caused by mutations of the TMEM230 or DNAJC13 genes. Fully referenced neurology checklist.

Genetics

  • This is probably caused by mutations of the TMEM230 or DNAJC13 genes
  • These are on chromosome 3q
  • The transmission is autosomal dominant
  • Lewy bodies are present

Clinical features

Locked: subscribe to see this section.

Treatment

Locked: subscribe to see this section.

References

  1. Deng HX, Shi Y, Yang Y, et al. Identification of TMEM230 mutations in familial Parkinson's disease. Nat Genet 2016; 48:733-739. 
  2. Vilariño-Güell C, Rajput A, Milnerwood AJ, et al. DNAJC13 mutations in Parkinson disease. Hum Mol Genet 2014; 23:1794-1801.

Related checklists

Loading...