Progressive supranuclear palsy (PSP): clinical features

Evidence-based neurology checklist on progressive supranuclear palsy (psp): clinical features: Core clinical domains Oculomotor dysfunction Postural instability Akinesia Cognitive dysfunction Facial features Ophthalmic features Postural and gait abnormalities Bulbar features Applause sign Postural…

Core clinical domains

  • Oculomotor dysfunction
  • Postural instability
  • Akinesia
  • Cognitive dysfunction

Facial features

Ophthalmic features

Postural and gait abnormalities

Bulbar features

Applause sign

Postural signs

Speech impairments

Other features

Poor prognostic markers

References

  1. Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol 2009; 8:270-279.
  2. Litvan I, Agid A, Calne D, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-PSP International Workshop. Neurology 1996; 47:1-9.
  3. Brazis PW, Masdeu JC, Biller J. Localization in Clinical Neurology. Lippincott Williams & Wilkins Philadelphia 2007 p445.
  4. Rojo A, Pernaute RS, Fontan A, et al. Clinical genetics of familial progressive supranuclear palsy. Brain 1999; 122:1233-1245.
  5. Höglinger GU, Respondek G, Stamelou M, et al; Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord 2017; 32:853-864. 
  6. And 23 more. Subscribe to see the full list

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