Progressive supranuclear palsy (PSP): treatment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Progressive supranuclear palsy (PSP): treatment. Levodopa, Dopamine agonists. Fully referenced neurology checklist.
Akinetic rigidity and freezing of gait
- Levodopa
- Dopamine agonists
- Rasagiline up to 1mg daily: especially for PSP-PGF
- Amantadine: up to a maximum of 100mg tid
- Liposomal Co-enzyme Q10 100mg tid
- Physical therapy
Dystonia
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Myoclonus
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Depression
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Sialorrhoea
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Insomnia
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Urinary urgency and incontinence
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Other symptoms
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Drugs to avoid
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Investigational treatments
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References
- Rowe JB, Holland N, Rittman T. Progressive supranuclear palsy: diagnosis and management. Pract Neurol 2021 (online ahead of print).
- Bluett B, Pantelyat AY, Litvan I, et al. Best practices in the clinical management of progressive supranuclear palsy and corticobasal syndrome: a consensus statement of the CurePSP Centers of Care. Front Neurol 2021; 12:694872.
- Nuebling G, Hensler M, Paul S, Zwergal A, Crispin A, Lorenzl S. PROSPERA: a randomized, controlled trial evaluating rasagiline in progressive supranuclear palsy. J Neurol 2016; 263:1565-1574.
- Höglinger GU, Litvan I, Mendonca N, et al. Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial. Lancet Neurol 2021; 20:182-192.
- Dam T, Boxer AL, Golbe LI, et al. Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial. Nat Med 2021; 27:1451-1457.
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