Restless legs syndrome (RLS): clinical features

Evidence-based neurology checklist on restless legs syndrome (rls): clinical features: Diagnostic features There is an urge to move This starts and is worse at rest There is relief with movement It is worse in the evening and at night There may be a positive family history There may be associated…

Diagnostic features

  • There is an urge to move
  • This starts and is worse at rest
  • There is relief with movement
  • It is worse in the evening and at night
  • There may be a positive family history
  • There may be associated periodic limb movements in sleep (PLMS)
  • There is improvement on Levodopa

Other features

Variants of RLS

RLS in men

Reasons for progression of RLS on treatment

Predictors of medication refractoriness

Predictors of RLS progression to a synucleinopathy

References

  1. Chahine LM, Chemali ZN. Restless legs syndrome: a review. CNS Spectr 2006; 11:511-520.
  2. Leschziner G, Gringras P. Restless legs syndrome. BMJ 2012; 344:e3056.
  3. Zhang C, Li Y, Malhotra A, Ning Y, Gao X. Restless legs syndrome status as a predictor of lower physical function. Neurology 2014; 82:1212-1218.
  4. Bayard S, Langenier MC, Dauvilliers Y. Decision-making, reward-seeking behaviors and dopamine agonist therapy in restless legs syndrome. Sleep 2013; 36:1501-1507.
  5. Perez-Diaz H, Iranzo A, Rye DB, Santamaria J. Restless abdomen: a phenotypic variant of restless legs syndrome. Neurology 2011; 77: 1283-1286.
  6. And 12 more. Subscribe to see the full list

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