Restless legs syndrome (RLS): investigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Restless legs syndrome (RLS): investigations. The subject is asked not to move for 1 hour. Fully referenced neurology checklist.

Suggested immobilisation test (SIT)

  • The subject is asked not to move for 1 hour
  • Symptoms and movements are monitored

Cerebrospinal fluid (CSF) analysis: features

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Magnetic resonance imaging (MRI) brain

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Transferrin receptor staining

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References

  1. Chahine LM, Chemali ZN. Restless legs syndrome: a review. CNS Spectr 2006; 11:511-520.
  2. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 2000; 54:1698-1700.
  3. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 2001; 56:263-265.
  4. Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired iron acquisition in restless legs syndrome. Neurology 2003; 61:304-309.

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