Sickle cell disease (SCD): investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Sickle cell disease (SCD): investigations. Red blood cells (RBC), White blood cells (WBC), Platelet count. Fully referenced neurology checklist.
Full blood count
- Red blood cells (RBC)
- White blood cells (WBC)
- Platelet count
- Haematocrit
- Haemoglobin (Hb)
- Mean corpuscular volume (MCV)
- Red cell distribution width (RDW)
Sickle cell detection tests
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Genetic testing techniques
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Transcranial Doppler (TCD)
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Magnetic resonance imaging (MRI) brain: sequences
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Magnetic resonance imaging (MRI): brain findings
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Magnetic resonance imaging (MRI): skeletal findings
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Emerging investigations
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References
- Arishi WA, Alhadrami HA, Zourob M. Techniques for the detection of sickle cell disease: a review. Micromachines (Basel) 2021; 12:519.
- Mallon D, Doig D, Dixon L, Gontsarova A, Jan W, Tona F. Neuroimaging in sickle cell disease: a review. J Neuroimaging 2020; 30:725-735.
- Mazzucco S, Diomedi M, Qureshi A, Sainati L, Padayachee ST. Transcranial doppler screening for stroke risk in children with sickle cell disease: a systematic review. Int J Stroke 2017; 12:580-588.
- Cherry MG, Greenhalgh J, Osipenko L, et al. The clinical effectiveness and cost-effectiveness of primary stroke prevention in children with sickle cell disease: a systematic review and economic evaluation. Health Technol Assess 2012; 16:1-129.
- Pegelow CH, Macklin EA, Moser FG, et al. Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood 2002; 99:3014-3018.
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