Tolosa Hunt syndrome (THS)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Tolosa Hunt syndrome (THS). This is low grade inflammation in the cavernous sinus and superior orbital fissure. Fully referenced neurology checklist.
Pathology
- This is low grade inflammation in the cavernous sinus and superior orbital fissure
Clinical features: painful unilateral ophthalmoplegia
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Clinical features: cranial nerve involvement
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Associated features
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Course
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Differential diagnosis
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Magnetic resonance imaging (MRI)
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Cerebrospinal fluid (CSF) analysis
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Treatment
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References
- Hunt WE, Meagher JN, LeFever HE, Zeman W. Painful ophthalmoplegia: its relation to indolent inflammation of the cavernous sinus. Neurology 1961; 11:56-62.
- Kline LB, Hoyt WF. The Tolosa-Hunt syndrome. JNNP 2001; 71:577-582.
- Madhavan AA, DeLone DR, Verdoorn JT. Bilateral facial nerve involvement in a patient with Tolosa-Hunt syndrome. Neuroradiol J 2020; 33:424-427.
- Arora H, Pasricha R, Sharma V. Tolosa-Hunt syndrome with anisocoria as the sole presenting ophthalmic sign. Prim Care Companion CNS Disord 2021; 23:20l02798.
- Yang Q, Lai C, Meng C, Chang Q, Wang J. Clinical and cerebrospinal fluid characteristics in 55 cases of tolosa-hunt syndrome: a retrospective analytical study. Eur Neurol 2022; 85:265-272.
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