Viral encephalitis: treatment

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Viral encephalitis: treatment. Intravenous Acyclovir, High dose oral Valaciclovir (HDVA). Fully referenced neurology checklist.

Treatment of infection

  • Intravenous Acyclovir
  • High dose oral Valaciclovir (HDVA)

Treatment duration

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Treatment of raised intracranial pressure

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Adjunctive steroids in viral encephalitis

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Indications for steroids in viral encephalitis

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References

  1. Solomon T, Michael BD, Smith PE, et al. Management of suspected viral encephalitis in adults-Association of British Neurologists and British Infection Association national guidelines. J Infect 2012; 64:347-373.
  2. Tunkel AR, Glaser CA, Bloch KC, et al. The management of encephalitis: clinical practice guidelines by the infectious diseases society of America. Clin Infect Dis 2008; 47:303-327.
  3. Solomon T, Hart IJ, Beeching NJ. Viral encephalitis: a clinician’s guide. Pract Neurol 2007; 7:288-305.
  4. Makishi N, Tokuda Y. Acyclovir encephalopathy in HSV encephalitis elderly with normal renal function. Case Rep Neurol Med 2025; 2025:3854205.
  5. Takahashi H, Takahashi Y, Hirayama T, Kamijo Y, Ezawa N, Furukawa T, Furutani R. Acyclovir-associated encephalopathy triggered by nonsteroidal anti-inflammatory drugs. J Rural Med 2025; 20:147-149.
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