Vogt-Koyanagi-Harada disease (VKHD): clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Vogt-Koyanagi-Harada disease (VKHD): clinical features. Fever, Headache, Nausea, Vertigo, Orbital pain, Tearing. Fully referenced neurology checklist.

Prodromal features: typical

  • Fever
  • Headache
  • Nausea
  • Vertigo
  • Orbital pain
  • Tearing
  • Photophobia
  • Neck stiffness
  • Confusion
  • Tinnitus

Prodromal features: others

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Ophthalmic symptoms

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Ophthalmic signs: acute

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Ophthalmic signs: chronic

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Dermatological features

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Other features

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References

  1. Lavezzo MM, Sakata VM, Morita C, et al. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis 2016; 11:29.
  2. Street D, Sivaguru A, Sreekantam S, Mollan SP. Vogt-Koyanagi-Harada disease. Pract Neurol 2019; 19:364-367. 
  3. Mili-Boussen I, Letaief I, Dridi H, Ouertani A. Bilateral retinal pigment epithelium tears in acute Vogt-Koyanagi-Harada disease. Retin Cases Brief Rep 2013; 7:350-354.
  4. Inomata H, Rao NA. Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease. Am J Ophthalmol 2001; 131:607-614.

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