Vogt-Koyanagi-Harada disease (VKHD): pathology

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Vogt-Koyanagi-Harada disease (VKHD): pathology. This is an autoimmune disease. The target are melanocyte antigens. Fully referenced neurology checklist.

Pathology

  • This is an autoimmune disease
  • The target are melanocyte antigens
  • There is an HLA DR4 predisposition

Triggers

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Risk populations

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Demographic features

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Clinical phases

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References

  1. Lavezzo MM, Sakata VM, Morita C, et al. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis 2016; 11:29.
  2. Sood AB, O'Keefe G, Bui D, Jain N. Vogt-Koyanagi-Harada disease associated with hepatitis B vaccination. Ocul Immunol Inflamm 2019; 27:524-527.
  3. Yoshino N, Kawamura A, Ishii A, et al. Vogt-Koyanagi-Harada disease associated with influenza A virus infection. Intern Med 2018; 57:1661-1665. 
  4. Dogan B, Erol MK, Cengiz A. Vogt-Koyanagi-Harada disease following BCG vaccination and tuberculosis. Springerplus 2016; 5:603. 
  5. Tieger MG, Eliott D, Cakir B, Dahrouj M. Checkpoint Inhibitor-Associated Vogt-Koyanagi-Harada disease presenting 3 months following discontinuation of nivolumab. Ophthalmic Surg Lasers Imaging Retina 2023; 54:183-187. 
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